| Pair Name | Capsaicin, Arsenic trioxide | ||
| Phytochemical Name | Capsaicin (PubChem CID: 1548943 ) | ||
| Anticancer drug Name | Arsenic trioxide (PubChem CID: 14888 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | Capsaicin, Arsenic trioxide | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | DIABLO | hsa56616 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | HL-60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| KG-1a | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_1824 | |
| Result | Combination index (CI) values were < 1 in all matched combination groups. Additional evaluation of As2O3 combined with ACM as a potential therapeutic benefit for AML seems warranted. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis. Leuk Lymphoma. 2015;56(11):3159-67. doi: 10.3109/10428194.2015.1011155. | Click |
